Frequently Asked Questions About Glioblastoma Multiforme
What Is Glioblastoma Multiforme?
Glioblastoma, also known as glioblastoma multiforme, is the most common primary malignant brain tumor among all brain tumors. It is also one of the most difficult tumors to treat. This tumor is a malignant tumor originating from the star-shaped glial support tissues in the brain, namely astrocytes.
How Often Is Glioblastoma Multiforme Seen and In Whom?
This tumor is seen in approximately 5 out of 100,000 people. GBM constitutes approximately 20-30% of all primary brain tumors. It is generally seen between the ages of 40-60 and slightly more often in men than in women.
What Are the Symptoms Seen in Glioblastoma?
The most common findings in glioblastoma are headache, memory loss, seizures, and behavioral changes. These findings occur due to the increased pressure resulting from the rapid growth of the tumor. As the tumor grows, loss of some bodily functions may occur depending on the characteristics of the area it presses on.
How Is Glioblastoma Diagnosed?
For the diagnosis of glioblastoma, the physician first performs a neurological examination. Then, the location and size of the tumor are determined with brain MRI. Confirmation of the diagnosis is possible with biopsy.
What Is the Aim of Treatment in Glioblastoma?
The aims of treatment in glioblastoma are as follows: Confirming the diagnosis Relieving symptoms Eliminating potentially treatment-resistant cells before they begin to multiply Reducing the number of malignant cells that the immune system has to cope with Exposing malignant cells to an oxygenated environment so that they become more sensitive to later treatment Reducing the amount of harmful products produced by malignant cells In order to achieve these, surgery is generally preferred. However, even after the most successful operation, microscopic tumor cells remain in the brain. In this case, the physician will recommend an additional treatment to kill as many of these cells as possible. This treatment plan may be either systemic, meaning it circulates through the body to the tumor region, or local, meaning it acts where the tumor is located.
How Common Is Glioblastoma Multiforme?
Glioblastoma multiforme is the most common and most aggressive among brain tumors. Approximately 3 out of 100,000 people worldwide are diagnosed with this disease each year.
Is Glioblastoma Multiforme Fatal?
Glioblastoma multiforme can be fatal if left untreated. Even if treated, the risk of recurrence is high due to the aggressive nature of the tumor. Untreated glioblastoma multiforme is usually fatal within a few months.
What Is the Cause of Glioblastoma Multiforme?
The exact cause of glioblastoma multiforme is unknown. However, various factors such as genetic factors, environmental factors, and lifestyle factors are thought to contribute to the development of this disease.
